Title: Professor and Chair
Organization: Pharmacy - Medicinal Chemistry
University of London,
London, United Kingdom,
Office Address: Medical Science Building, P6-20
Email: firstname.lastname@example.orgTelephone: +1 (352) 273-7707
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Uptake and biotransformation of xenobiotics.
Factors affecting the metabolism and toxicity of drugs and other xenobiotics in humans and animal species, including aquatic species. This laboratory studies mechanisms of uptake, biotransformation, excretion and toxicity of xenobiotics, especially environmental chemicals. Another interest is the influence of xenobiotics on the metabolism of hormones. Techniques used include enzyme assays, analytical chemistry, enzyme purification, molecular biology, radiochemistry
James MO Stuchal LD, and Nyagode BA. Glucuronidation and sulfonation in vitro of the major endocrine-active metabolites of methoxychlor in the channel catfish, Ictalurus punctatus, and induction following treatment with 3-methylcholanthrene. Aquatic Toxicology 86: 227-238, 2008
Wang, L.Q., Falany, C.N. and James, M.O. Triclosan as a substrate and inhibitor of 3’-phosphoadenosine-5’-phosphosulfate sulfotransferase and UDP-glucuronosyl transferase in human liver fractions. Drug Metabolism and Disposition, 32: 1162-1169, 2004
Effects of water contaminants on steroid hormone biotransformation.
Wang, L.Q. and James, M.O. Sulfonation of 17beta-estradiol and inhibition of sulfotransferase activity by polychlorobiphenylols and celecoxib in Channel catfish, Ictalurus punctatus. Aquatic Toxicology, 81: 286-292, 2007
Keywords: toxicity; drugs; xenobiotics; biotransformation; steroids; hormones
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