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Name: James, Margaret
Title: Professor and Chair
Organization: Pharmacy - Medicinal Chemistry
Education: Ph.D., Chemistry, University of London, London, United Kingdom, 1972
Office Address: Medical Science Building, P6-20
Email: mojames@ufl.edu
Telephone: +1 (352) 273-7707

Google Scholar Profile link:

Uptake and biotransformation of xenobiotics. Factors affecting the metabolism and toxicity of drugs and other xenobiotics in humans and animal species, including aquatic species. This laboratory studies mechanisms of uptake, biotransformation, excretion and toxicity of xenobiotics, especially environmental chemicals. Another interest is the influence of xenobiotics on the metabolism of hormones. Techniques used include enzyme assays, analytical chemistry, enzyme purification, molecular biology, radiochemistry Selected Publications: James MO Stuchal LD, and Nyagode BA. Glucuronidation and sulfonation in vitro of the major endocrine-active metabolites of methoxychlor in the channel catfish, Ictalurus punctatus, and induction following treatment with 3-methylcholanthrene. Aquatic Toxicology 86: 227-238, 2008 Wang, L.Q., Falany, C.N. and James, M.O. Triclosan as a substrate and inhibitor of 3’-phosphoadenosine-5’-phosphosulfate sulfotransferase and UDP-glucuronosyl transferase in human liver fractions. Drug Metabolism and Disposition, 32: 1162-1169, 2004 Effects of water contaminants on steroid hormone biotransformation. Wang, L.Q. and James, M.O. Sulfonation of 17beta-estradiol and inhibition of sulfotransferase activity by polychlorobiphenylols and celecoxib in Channel catfish, Ictalurus punctatus. Aquatic Toxicology, 81: 286-292, 2007

Keywords: toxicity; drugs; xenobiotics; biotransformation; steroids; hormones